Tadalafil: How Does It Work in the Body?
What is tadalafil?
Tadalafil is the main ingredient in Cialis and is a type of PDE5 inhibitor.
Tadalafil is also available as a generic medicine under the same name.
It works by limiting the activity of enzymes, and increasing blood flow to the penis to improve erectile potency.
What makes tadalafil different to other ED treatments?
Erectile dysfunction is an area of medicine which has seen significant development over the course of the past decade.
From 1998 to 2002, there were only two treatments available for the condition (one of which is now a household name) before a handful of others emerged in years that followed.
Cialis was released onto the market by Lilly in 2003, and has since been available to buy online with a prescription. It contains a PDE5 inhibitor called tadalafil, whereas previous ED treatments contained sildenafil citrate (also a PDE5 inhibitor) or alprostadil (a prostaglandin).
Known also as the ‘weekend pill’, the durable half-life of Cialis (17.5 hours, making it active for up to 36 hours) sets it apart from those treatments with a shorter half-life which have to be applied on demand.
Cialis is sold in ‘daily’ form too, whereby the user takes one pill per day to provide complete round the clock coverage.
What is a PDE5 Inhibitor?
This type of medicine functions by blocking the action of an enzyme called PDE5 (full name: cGMP-specific phosphodiesterase type 5).
When a man becomes aroused, nerve endings trigger a release in nitric oxide which stimulates the action of a chemical called cGMP.
cGMP, or cyclic guanosine monophosphate, acts a messaging conduit. It plays a vital role in the dilation of blood vessels, which is important for the movement of blood around various parts of the body.
The penis is one such region. cGMP synthesis allows blood to fill the corpus cavernosum, a tissue channel in the penis. Once blood rushes to this area, an erection is the result.
PDE5 is an enzyme which takes on cGMP and unbinds it. In some, this means that the flow of blood becomes impaired, leading to circulation problems; one of which is erectile dysfunction.
The job of a PDE5 inhibitor then, is to prevent this enzyme from breaking cGMP down, so that blood flow becomes increased. Subsequently, blood can fill the muscles in the penis more easily, facilitating stronger and firmer erections.
In addition to having a longer half-life than sildenafil and vardenafil, tadalafil has been found to be more selective in the way it inhibits PDE. By having less of an effect on PDE6, an enzyme mostly found in the eye, it is consequently thought less likely to produce ocular side effects such as photosensitivity.
How can I buy tadalafil?
Because it is a prescription-only medicine, you will need to consult with a doctor before purchasing tadalafil in person or online.
Some men with certain medical conditions, such as Parkinson’s disease or multiple sclerosis, may be able to get Cialis on an NHS prescription.
For most men, a private prescription will be needed to buy Cialis. Men will need to purchase it at market price rather than at the NHS levy rate if they don’t have an NHS prescription for it.
The market price of Cialis can vary, depending on where you get it from.
In 2017, the generic version of Cialis, Tadalafil, became available. However, at time of writing, the provision of the generic version on the NHS was still under consideration.
Our private consultation facility enables you to have your case reviewed by a qualified physician. It takes just a few minutes, and once your prescription has been approved, our UK pharmacy will ship your treatment right to your door within one working day.
Read our page on safe buying practices to find out more about getting impotence treatment online.
- 39Some men with erectile dysfunction, or ED, find they can return to an active sex life by treating an underlying condition, such as high blood pressure, or with counseling and lifestyle changes. But others find they may need medication to get and keep an erection. The FDA has approved several…